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Πλοήγηση ανά Συγγραφέα "Taratsas, Andreas"

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    Analysis of temporal drug prescription data to detect extremes and patterns using statistical process control tools
    (2025-10-07) Taratsas, Andreas; Ταράτσας, Ανδρέας; Pateras, Konstantinos; Vrontos, Ioannis; Psarakis, Stelios
    This dissertation analyzes temporal prescription data from the national ePrescription system (IDIKA) using Statistical Process Control (SPC) and time series modelling techniques to identify deviations, structural changes, and underlying prescribing patterns. Data were provided by IDIKA and included multiple ATC-coded pharmaceutical substances. A descriptive statistical analysis was first conducted to explore variability and behavioral dynamics across drugs. Four representative substances (M04AC01, M09AX01, L04AC16, and L04AC18) were selected based on diversity in variability, periodicity, and pattern change. Subsequently, an ARIMA modelling framework was applied to the daily prescription counts to extract residuals free of autocorrelation, which were then analyzed through Shewhart control charts. The Phase I–II approach ensured unbiased estimation of control limits and allowed for process stability assessment over time. Results for M09AX01 demonstrated that the prescribing process remained largely in control, with transient fluctuations attributed to external factors such as policy or supply effects. The findings highlight the applicability of SPC methods—traditionally used in industrial quality control—to healthcare analytics, offering an operational early-warning mechanism for monitoring pharmaceutical utilization and supporting data-driven decision-making within IDIKA.